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7 _. }6 z2 }9 c/ `6 J! |! Y' g; {7 `+ k2004年
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L. Feng, D. A. Gell, S. Zhou, L. Gu, Y. Kong, J. Li, M. Hu, N. Yan, C. Lee, A. M. Rich, R. S. Armstrong, P. A. Lay, A. J. Gow, M. J. Weiss, J. P. Mackay, and Y. Shi1, Molecular Mechanism of AHSP-Mediated Stabilization of-Hemoglobin, Cell 119, 629–640 (2004).
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" d4 c7 U2 c/ c6 H, ?7 U6 V" x2005年; E$ L# b3 _3 \* C4 q
5 C9 W" ~6 A* O9 j8 _5 R0 w F& |& ON. Yan, J. Chai, E. S. Lee, L. Gu, Q. Liu, J. He, J. W. Wu, D. Kokel, H. Li, Q. Hao, D. Xue, and Y. Shi, Structure of the CED-4–CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans, Nature 437, 831–837 (2005)./ s# n* i4 @/ T) y6 `5 [
6 @) j% E7 {+ J- e
2006年$ I6 [! e# U- x5 ]( d# V0 C
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2007年
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! p! ~: K6 f* ]! {8 m' }; jL. Feng, H. Yan, Z. Wu, N. Yan, Z. Wang, P. D. Jeffrey, and Y. Shi, Structure of a Site-2 ProteaseFamily Intramembrane Metalloprotease, Science 318, 1608-1612 (2007).2 n% |3 y% m' T+ B# n# \& f* N
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2008年
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2009年& F; P4 j( t8 W/ g! a z
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Y. Wang, Y. Huang, J. Wang, C. Cheng, W. Huang, P. Lu, Y. N. Xu, P. Wang, N. Yan, and Y. Shi, Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel, Nature 462, 467–472 (2009).7 {, ^5 ?- ?! ?0 n0 b) |1 V
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2010年
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: [1 @3 E2 p AS. Dang, L. Sun, Y. H., F. Lu, Y. Liu, H. Gong, J. Wang, and N. Yan, Structure of a fucose transporter in an outward-open conformation, Nature 467, 734–738 (2010).
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7 U$ [% B) V1 U6 x, y' i* j1 rS. Qi, Y. Pang, Q. Hu, Q. Liu, H. Li, Y. Zhou, T. He, Q. Liang, Y. Liu, X. Yuan, G. Luo, H. Li, J. Wang, N. Yan, and Y. Shi, Crystal Structure of the Caenorhabditis elegans Apoptosome Reveals an Octameric Assembly of CED-4, Cell 141, 446–457 (2010).
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2011年
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F. Lu, S. Li, Y. Jiang, J. Jiang, H. Fan, G. Lu, D. Deng, S. Dang, X. Zhang, J. Wang, and N. Yan, Structure and mechanism of the uracil transporter UraA, Nature 472, 243–246 (2011).
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2012年
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7 [8 i" Z _8 R4 ND. Deng, C. Yan, X. Pan, M. Mahfouz, J. Wang, J. K. Zhu, Y. Shi, N. Yan, Structural Basis forSequence-Specific Recognition ofDNA by TAL Effectors, Science 335, 720-723 (2012).
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* z: H8 `1 B0 h2 aX. Zhang, W. Ren, P. DeCaen, C. Yan, X. Tao, L. Tang, J. Wang, K. Hasegawa, T. Kumasaka, J., J. Wang, D. E. Clapham, and N. Yan, Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel, Nature 486, 130–134 (2012).
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* w M: {# y( [L. Sun, X. Zeng, C. Yan, X. Sun, X. Gong, Y. Rao, and N. Yan, Crystal structure of a bacterial homologue of glucose transporters GLUT1–4, Nature 490, 361–366 (2012).1 E5 q7 i) L e9 P" O
* }0 S9 c" {9 s* D4 q2013年
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P. Yin, Q. Li, C. Yan, Y. Liu, J. Liu, F. Yu, Z. Wang, J. Long, J. He, H. W. Wang, J. Wang, J. K. Zhu, Y. Shi, and N. Yan, Structural basis for the modular recognition of single-stranded RNA by PPR proteins, Nature 504, 168–171 (2013)., D! v: Y5 Z. ~
: T& E4 e' ]4 `) o. G4 D8 E7 T2014年
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D. Deng, C. Xu, P. Sun, J. Wu, C. Yan, M. Hu, and N. Yan, Crystal structure of the human glucose transporter GLUT1, Nature 510, 121–125 (2014). `2 u& z# ^6 H. x
/ y& P9 M8 n" H( @" q3 r2015年1 r* s8 P, O5 o6 a, p
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Z. Yan, X. Bai, C. Yan, J. Wu, Z. Li, T. Xie, W. Peng, C. Yin, X. Li, S. H. W. Scheres, Y. Shi, and N. Yan, Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution, Nature 517, 50–55 (2015).
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/ G* E8 u( N5 ]; S- gD. Deng, P. Sun, C. Yan, M. Ke, X. Jiang, L. Xiong, W. Ren, K. Hirata, M. Yamamoto, S. Fan, and N. Yan, Molecular basis of ligand recognition and transport by glucose transporters, Nature 526, 391–396 (2015).
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, ^1 g( I0 e YJ. Wu, Z. Yan, Z. Li, C. Yan, S. Lu,M. Dong, and N. Yan, Structure of the voltage-gatedcalcium channel Cav 1.1 complex Science 350, aad2395 ( 2015).
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R. Ren, X. Zhou, Y. He, M. Ke, J. Wu, X. Liu, C. Yan, Y. Wu, X. Gong, X. Lei, S. F. Yan, A. Radhakrishnan, ,and N. Yan, Crystal structure of a mycobacterialInsig homolog provides insight intohow these sensors monitor sterol levels, Science 349, 187-191 (2015).
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2016年
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8 o- b5 u0 x- r+ |# UX. Gong, H. Qian, X. Zhou, J. Wu, T. Wan, P. Cao, W. Huang, X. Zhao, X. Wang, P. Wang, Y. Shi, G. F. Gao, Q. Zhou, and N. Yan, Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection, Cell 165, 1467–1478 (2016).0 w( x8 r" L3 Z- Z% W: ]* c, \) E! f) \
- F6 L: h3 a/ S+ ]' i& A( xJ. Wu, Z. Yan, Z. Li, X. Qian, S. Lu, M. Dong, Q. Zhou, and N. Yan, Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution, Nature 537, 191–196 (2016).: s7 @8 R. G9 e' A8 q7 ^3 C5 a
; S3 U: b( ]; X. f/ U- P" m4 g# sW. Peng, H. Shen, J. Wu, W. Guo, X. Pan, R. Wang, S. R. W. Chen, and N. Yan, Structural basis for the gatingmechanism of the type 2 ryanodinereceptor RyR2 Science 354, aah5324 ( 2016).
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, @, D( X1 p0 F; l2 Y: [ Z0 T9 v2017年* a, h- n4 S7 i4 W' F: w5 O% r
7 s( E/ p# l/ y% u& J1 f5 ^+ J4 ~
H. Qian, X. Zhao, P. Cao, J. Lei, N. Yan, and X. Gong, Structure of the Human Lipid Exporter ABCA1, Cell 169, 1228–1239 (2017).
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1 I+ c) T! W$ L6 w. wZ. Yan, Q. Zhou, L. Wang, J. Wu, Y. Zhao, G. Huang, W. Peng, H. Shen, J. Lei, and N. Yan, Structure of the Nav1.4-bComplex from Electric Eel, Cell 170, 470–482 (2017).
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, G0 ?! _! t: N) v/ U9 s% OH. Shen, Q. Zhou, X. Pan, Z. Li, J. Wu, and N. Yan, Structure of a eukaryoticvoltage-gated sodium channelat near-atomic resolution, Science 355, eaal4326 (2017)./ }5 ^/ N6 C- C4 l! k: J* u3 ~- w2 J4 f
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2018年
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7 \- g/ V# p N8 q$ BX. Pan, Z. Li, Q. Zhou, H. Shen, K. Wu,X. Huang, J. Chen, J. Zhang, X. Zhu, J. Lei,W. Xiong, H. Gong, B. Xiao, and N. Yan, Structure of the human voltage-gatedsodium channel Nav 1.4 in complex with beta1, Science 362, eaau2486 (2018).
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" s. e3 _2 D; D. J. V2 v2 UH. Shen, Z. Li, Y. Jiang, X. Pan, J. Wu,B. Cristofori-Armstrong, J. J. Smith, Y. K.Y. Chin, J. Lei, Q. Zhou, G. F. King, and N. Yan, Structural basis for the modulationof voltage-gated sodium channelsby animal toxins Science 362, eaau2596 (2018).
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% l* \; D0 K. c! E# T5 |X. Gong, H. Qian, P. Cao, X. Zhao, Q. Zhou, J. Lei, and N. Yan, Structural basis for the recognition ofSonic Hedgehog by human Patched1, Science 361, eaas8935 (2018).
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; L1 U" N1 ] `% G. D8 L2019年
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& C' D* r, \% @7 U, jY. Zhao, G. Huang, J. Wu, Q. Wu, S. Gao, Z. Yan, J. Lei, and N Yan, Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel, Cell 177, 1495–1506 (2019).
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$ Z1 {3 W# U; J, X5 K: J& ?: _- yY. Zhao, G. Huang, Q. Wu, K. Wu, R. Li, J. Lei, X. Pan, and N. Yan, Cryo-EM structures of apo and antagonist-bound human Cav3.1, Nature 576, 492–497 (2019). B, f" n* J+ ?# j4 C) M! D7 p
: R6 d" m) m2 n( w0 w E, |D. Gong, X. Chi, J. Wei, G. Zhou, G. Huang, L. Zhang, R. Wang, J. Lei, S. R. W. Chen, and N. Yan, Modulation of cardiac ryanodine receptor 2 by calmodulin, Nature 572, 347–351 (2019).- k @$ C. r+ B, ?4 e
8 l- O, q# S! p& A( k8 mH. Shen, D. Liu, K. Wu, J. Lei, and N. Yan, Structures of human Nav 1.7 channel in complex with auxiliary subunits and animal toxins, Science 363, 1303-1308 (2019).+ P/ a+ h0 g" U6 C
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X. Pan, Z. Li, X. Huang, G. Huang, S. Gao, H. Shen, L. Liu, J. Lei, and N. Yan, Molecular basis for pore blockade of human Na+ channel Nav 1.2 by the m-conotoxin KIIIA, Science 363, 1309-1313 (2019). l6 |; A3 l+ c" P1 y
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2020年, ^9 Y" R1 j5 \. Y$ W
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H. Qian, X. Wu, X. Du, X. Yao, X. Zhao, J. Lee, H. Yang, and N. Yan, Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2 Cell 182, 98–111 (2020).
* M/ b! l$ b3 ~: A4 n6 C# L7 s/ w) L, M9 c. F# o/ F
X. Jiang, Y. Yuan, J. Huang, S. Zhang, S. Luo, N. Wang, D. Pu, N. Zhao, Q. Tang, K. Hirata, X. Yang, Y. Jiao, T. Sakata-Kato, J. W. Wu, C. Yan, N. Kato, H. Yin, and N. Yan, Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum, Cell 183, 258–268 (2020)
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+ D$ S# ~$ b. B8 j# [H. Qian, X. Zhao, R. Yan, X. Yao, S. Gao, X. Sun, X. Du, H. Yang, C. C. L. Wong, and N. Yan, Structural basis for catalysis and substrate specificity of human ACAT1, Nature 581, 333–338 (2020).
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L. Wang, H. Qian, Y. Nian, Y. Han, Z. Ren, H. Zhang, L. Hu, B. V. V. Prasad, A. Laganowsky, N. Yan, and M. Zhou, Structure and mechanism of human diacylglycerol O-acyltransferase1, Nature 581, 329–332 (2020).3 }7 Y( X, S! J1 ?- q; A
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2021年; z% [6 A4 w5 r- e
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S. Gao, X. Yao, and N. Yan, Structure of human Cav2.2 channel blocked by the painkiller ziconotide, Nature 596, 143–147 (2021).1 ^$ T+ I8 y( _# O0 k- N6 R' b
1 I$ ]2 C: w o" nR. Yan, P. Cao, W. Song, H. Qian, X. Du, H. W. Coates, X. Zhao,Y. Li, S. Gao, X. Gong, X. Liu, J. Sui, J. Lei, H. Yang, A. J. Brown, Q. Zhou, C. Yan, and N. Yan, A structure of human Scap bound to Insig-2 suggestshow their interaction is regulated by sterols, Science 371, eabb2224 (2021).2 B+ t5 g9 r- Q# G5 i' i
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2022年
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X. Yao, S. Gao, J. Wang, Z. Li, J. Huang, Y. Wang, Z. Wang, J. Chen, X. Fan, W. Wang, X. Jin, X. Pan, Y. Yu, A. Lagrutta, and N. Yan, Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels, Cell 185, 4801–4810 (2022).
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' V' A+ T) \6 u: w6 MC. A. Lutomski, T. J. El-Baba, C. V. Robinson, R. Riek, S. H. Scheres, N. Yan, M. AlQuraishi, and L. Gan, The next decade of protein structure, Cell 185, 2617–2620 (2022).
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. z5 I8 a8 \4 c5 q2 Q8 l6 P, U1 L. W2023年7 M! B3 [- D. T) V! t
9 |" c. i N4 b8 I) w9 VS. Gao, X. Yao, J. Chen, G. Huang, X. Fan, Li. Xue, Z. Li, T. Wu, Y. Zheng, J. Huang, X. Jin, Y. Wang, Z. Wang, Y. Yu, L. Liu, X. Pan, C. Song, and N. Yan, Structural basis for human Cav1.2 inhibition by multiple drugs and the neurotoxin calciseptine, Cell 186, 5363–5374 (2023).% a* U- p4 M2 d( {' n1 U C
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2024年* j+ c$ y) M4 j$ o& c* U/ t
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J. Huang, H. Tao, J. Chen, Y. Shen, J. Lei, J. Pan, C. Yan, and N. Yan, Structure-guided discovery of protein and glycan components in native mastigonemes, Cell 187, 1733–1744 (2024).
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Y. Zhao, G. Huang, Q. Wu, K. Wu, R. Li, J. Lei, X. Pan, and N. Yan, Author Correction: Cryo-EM structures of apo and antagonist-bound human Cav3.1, Nature 630, E6 (2024).8 t2 R8 j3 t( U$ z' W: g
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2025年以来还没有CNS，而且截止到目前，很奇怪2025年只发表了6篇文章。像她这种大佬，发文章跟喝水一样，可是在2019年发表了5篇CNS，都差点集成了2个CNS的大满贯。 |
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